Table of Contents

List of Contributors xxi

Preface xxv

Part A Principles 1

A.1 Delivering Energy 3

1 Propagation of Radiofrequency and Microwaves in Tissue 5
Punit Prakash and Anna Bottiglieri

2 Propagation of Focused Ultrasound in Tissue 19
Gregory T. Clement

3 Propagation of Light in Tissue 31
Do-Hyun Kim

4 Mechanisms of Tissue Injury in Cryosurgery 45
John G. Baust, Kimberly L. Santucci, Kristi K. Snyder, Anthony Robilotto, and John M. Baust

5 Delivering Energy using Localized Hyperthermia Systems 73
Hana Dobsicek Trefna, Johannes Crezee, and Petra Kok

6 Role of Nanoparticles Mediated Heating in Oncology 95
Gennaro Bellizzi

A.2 Assessing Temperatures 107

7 Temperature Monitoring During Thermal Treatment by Thermocouples and Thermistors: Current Status and Perspectives 109
Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena

8 Fluorescent-Decay Temperature Probes for Biomedical Applications: Theory, Techniques, and Practical Advice 121
Daryl James and Harry Vine

9 Calibration and Use of Infrared Thermal Cameras in Biological Applications 135
Michael L. Denton and Gary D. Noojin

10 Magnetic Resonance Thermometry in Oncology: Applications in Moving Organs 149
Henrik Odéen and Dennis L. Parker

11 Measuring Tissue Temperature with Ultrasound 175
Elyas Shaswary and Jahangir (Jahan) Tavakkoli

12 Current Status and Future Potential of Thermometry Based on Computed Tomography Imaging 195
Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena

13 A Generic Thermal Model to Predict Temperatures in Perfused Tissues 205
Devashish Shrivastava

A.3 Assessing Damage 217

14 Measuring Thermal Damage with Gross and Microscopic Pathology 219
Sharon Thomsen

15 Assessing Thermal Damage with Magnetic Resonance Imaging 251
Sara L. Johnson and Allison H. Payne

16 Ultrasound Imaging Techniques for the Evaluation of Thermal Damage 273
Jenna Osborn

17 Mathematical Models of Thermal Damage and Cell Death 289
John Pearce

18 A Novel Method to Indicate Onset of Photothermal Damage 307
Michael L. Denton, Gary D. Noojin, and Elharith M. Ahmed

19 Thermodynamic Challenges of Using Magnetic Resonance Thermometry in Measuring in vivo Temperatures and Estimating Thermal Damage in Thermal Ablation 329
Devashish Shrivastava

Part B Clinical Applications 341

20 Biological and Physical Aspects of Heat Therapy 343
Abhijit Mandal, Ritusha Mishra, and Himanshu Mishra

21 Guiding Thermal Therapy with MR 359
Richard Tyc and Mark G. Torchia

22 Role of Radiofrequency Ablation and Laser-Induced Thermal Therapy in the Management of Functional Neurosurgery and Brain Lesions 377
Peter Konrad, Johnie Hodge, and Manish Ranjan

23 Radiofrequency and Microwave Thermal Ablation in Cancer Therapy and the Role of Hydrodissection 391
Arvind K. Chaturvedi

24 Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions 403
Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, and W. Jeffrey Elias

25 Role of HIFU in Cancer Management 425
Sofia Gereta, Judith Stangl-Kremser, Tenny R. Zhang, and Jim C. Hu

26 Percutaneous Cryoablation: Mechanism of Action, Clinical Applications, and Outcomes 459
Ahmed Farhan, Christopher R. Bailey, and Christos Georgiades

27 Clinical Applications of Hyperthermia 483
Himanshu Mishra, Ritusha Mishra, and Abhijit Mandal

28 Thermal Damage due to a Monopole Microwave Antenna 499
Marta Cavagnaro and Devashish Shrivastava

29 Thermal Damage with High-Intensity Focused Ultrasound 511
Devashish Shrivastava

30 Thermal Damage Due to Laser 519
Rahul Goyal and Devashish Shrivastava

31 Thermal Damage Due to Hot and Cold Surfaces 525
Devashish Shrivastava

32 MRI-Induced RF Heating Considerations for Devices and Accessories that are Partially in and Partially Out of the Human Body 533
Ran Guo, Md Zahidul Islam, Wolfgang Kainz, and Ji Chen

References 542

Index 545

About the Author

Devashish Shrivastava is a mechanical engineer with In Vivo Temperatures, LLC, Clarksville, MD, USA with a background in the assessment of in vivo tissue heating and resulting thermal damage with over 80 publications. He is also the editor of two other books, Theory and Applications of Heat Transfer in Humans and Safety and Biological Aspects in MRI.