Table of Contents

Introduction to the Chemical Modification of Proteins. Alkylating Agents. Acylating Agents. Nitration and Nitrosylation. Oxidation. Modification of Proteins with Reducing Agents. Chemical Modification of Cysteine. Modification of Sulfhydryl Groups in Proteins for Analysis. Conjugate Nucleophilic Addition (Michael Addition). Alkyl Alkanethiosulfonates. Chemical Modification of Cystine. Cleavage of Disulfide Bonds. Modification of Methionine. Modification of Carboxyl Groups in Proteins. Modification of Tyrosine Residues. Modification of Tryptophan. Modification of Amino Groups. Modification of Histidine. Modification of Arginine. Index.

About the Author

Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD in biochemistry from the University of Washington. After his postdoctoral work in the laboratories of Stanford Moore and William Stein at The Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He then joined the Hyland Division of Baxter Healthcare in 1990. Currently, Dr. Lundblad works as an independent consultant at Chapel Hill, North Carolina, and writes on biotechnological issues. He is an adjunct professor of pathology at the University of North Carolina at Chapel Hill.