Table of Contents

Contributors; Preface; 1. Introduction: gene therapy approaches to cancer Brian E. Huber; 2. Principles of transformation-directed cancer therapy Ian Magrath and Kishor Bhatia; 3. Vectors for cancer gene therapy Prem Seth; 4. Genetically engineering drug sensitivity and drug resistance for the treatment of cancer Brian E. Huber; 5. Oncogene inactivation and replacement strategies for cancer Jack A. Roth; 6. Genetically modified tumor cells as tumor vaccines John C. Krauss, Suyu Shu and Alfred E. Chang; 7. Genetically modified lymphocytes and hematopoietic stem cells as therapeutic vehicles Patrick J. Geraghty and James J. Mulé; 8. Pharmacologic effects of oligonucleotides and some clinical applications Leonard M. Neckers and Kanak Iyer; 9. Current status of gene marking and gene therapy in oncology clinical trials Cynthia A. Richards; 10. Safety testing for gene therapy products J. Patrick Condreay; Index.

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Reviews progress and considers future developments in the fast-evolving field of gene therapy in oncology.