Table of Contents

1: Lessons From Haemoglobin
2: Finding Genes and Specific Genetic Variants Responsible for Disease
3: Cytogenetics and Large Scale Structural Genomic Variation
4: Submicroscopic Structural Variation in Health and Susceptibility to Disease
5: Submicroscopic Structural Variation and Genomic Disorders
6: Segmental Duplications and Indel Polymorphisms
7: Tandem Repeats
8: Mobile DNA Elements
9: SNPs, HapMap and Common Disease
10: Fine Scale Sequence Diversity and Signatures of Selection
11: Genetics of Gene Expression
12: Extreme Diversity in the Major Histocompatibility Complex
13: Parasite Wars
14: Human Genetic Diversity and HIV: Lessons From a War Fought on Many Fronts
15: Concluding Remarks and Future Directions
Glossary
References
Index

About the Author

Julian Knight gained a BA from the University of Cambridge in 1989, subsequently qualifying in medicine from the University of Edinburgh in 1992. Following junior hospital posts in Edinburgh and Newcastle, he did his DPhil at the Weatherall Institute of Molecular Medicine in Oxford. In 1999 he began post-doctoral research as an MRC Clinician Scientist in Oxford and Harvard. He has been a Wellcome Trust Senior Research Fellow in Clinical Science at the Wellcome
Trust Centre for Human Genetics in Oxford since 2005 and is an honorary Consultant in Internal Medicine at the John Radcliffe Hospital. He was elected fellow of the Royal College of Physicians in 2007 and
was awarded the Linacre Medal by the Royal College of Physicians in 2008. His current research programme investigates the functional consequences of genetic variation for genetic variation for gene regulation with a particular interest in immune and infectious disease.