Table of Contents

MECHANISMS OF ALLERGIC ASTHMA

Human T Helper Type 1 and Type 2 Subsets
Hans Yssel
Mechanisms of Allergic Asthma: A Th2 Disease
Douglas S. Robinson and A. Barry Kay
Mechanisms of Asthma: Asthma Is an Allergic Disease
Lisa M. Wheatley and Thomas A. E. Platts-Mills
Inflammation and Airway Remodeling in Asthma
Jean Bousquet, Pascal Chanez, Antonio M. Vignola, and Philippe Godard
The Prognosis and Natural History of Asthma
Jorrit Gerritsen, Marion H. Grol, Jan P. Schouten, and Dirkje S. Postma

ALLERGEN-SPECIFIC IMMUNOTHERAPY

Current Knowledge

Allergen Immunotherapy: Therapeutic Vaccines for Allergic Diseases (WHO Position Paper, Executive Summary)
Jean Bousquet, Richard F. Lockey, and Hans-Jørgen Malling
Allergen-Specific Immunotherapy: New Strategies Using Recombinant Allergens
Alisa M. Smith and Martin D. Chapman
Elimination of Allergens
Frédéric de Blay, François Spirlet, Martine Ott, Jean-Claude Bessot, and Gabrielle Pauli
Standardization of Allergens
Jean Bousquet and François-Bernard Michel
Allergen-Specific Immunotherapy: Past and Present
Philip S. Norman
Allergen-Specific Immunotherapy: Mechanisms of Immunotherapy
Jérôme Pène and Jean Bousquet
Objectives of Immunotherapy in Asthma
Anthony J. Frew
Allergen-Specific Immunotherapy for Asthma: Metaanalysis of Randomized Controlled Trials
Michael J. Abramson, Robert M. Puy, and John M. Weiner
Noninjective Immunotherapy: Present Knowledge and Experimental Evidence
Giovanni Passalacqua, Gian Enrico Senna, and Giorgio Walter Canonica
Pediatric Issues in Immunotherapy
Errka Valovirta
International Recommendations
Hans-Jørgen Malling

New Forms of Specific Immunotherapy

Peptide-Mediated Immunomodulation as Therapy for Allergic Disorders
Nanna S. Kristensen, Hans Yssel, and Jonathan R. Lamb
Potential of Recombinant Allergens as Immunotherapeutic Agents for Allergy and Asthma
Shyam S. Mohapatra
Molecular Characterization of Allergens, Their B-Cell Epitopes, and Allergen-Specific Antibodies for Allergy Prevention and Treatment
Rudolf Valenta, Susanne Vrtala, Tanja Ball, Sylvia Laffer, Petra Eibensteiner, Peter Steinberger, Sabine Flicker, Sabine Fischer, Irene Mittermann, Susanne Spitzauer, and Dietrich Kraft
Tolerogenic Peptides: Clinical Experience in Allergy
Christopher F. Nicodemus and George Philip
Manipulation of the Idiotypic Network: An Alternative Approach to Treat Allergic Asthma?
Yvan Boutin and Jacques Hébert
The Use of Allergen-Specific Antibodies for Immunotherapy
Jean-Marie R. Saint-Remy

REGULATION OF IgE INFLAMMATION

Immunoglobulin

Anti-Immunoglobulin E Therapy for Asthma
Pascal Demoly, Dany Jaffuel, and Jean Bousquet

Immunoglobulin Receptors

Expression and Function of the High-Affinity Receptor for Immunoglobulin E in Asthma
Marie-Hélàne Jouvin and Jean-Pierre Kinet
Factors Modulating Allergen-Induced Histamine Release: Fc-Receptors, Antibodies, and Allergens
Ronald van Ree
Regulation of Immunoglobulin E-Mediated Inflammation by Soluble Fragments of the High-Affinity Immunoglobulin E Receptor
Brian J. Sutton and Hannah J. Gould
Regulation of Immunoglobulin E Inflammation: Anti-Immunoglobulin E Autoantibodies
Beda M. Stadler, Monique Vogel, Michael P. Rudolf, Sylvia Margaret Miescher, Adrian Walter Zuercher, and Franz Kricek

NON-IMMUNOGLOBULIN E-DEPENDENT IMMUNOTHERAPY

Non-Immunoglobulin E-Dependent Immunotherapy: Treatment of Asthma with Inhaled Interferon Gamma
Gideon Lack, Donald Y. M. Leung, and Erwin W. Gelfand
Role of Interleukin-5 in Eosinophil-Based Diseases
Francis M. Cuss, Richard W. Chapman, Shelby P. Umland, Michael Minnicozzi, and Robert W. Egan

PREVENTION OF ALLERGIC ASTHMA: IS IT POSSIBLE?

Primary Prevention of Atopic Asthma: Prophylactic Strategies Based on Immunomodulation of Host Responses During Childhood
Patrick G. Holt
Outdoor Air Pollution and Asthma
Erika von Mutius
The Genetic Basis of Allergy and Asthma
Pamela J. Amelung and Eugene R. Bleecker
Gene Therapy Strategies for Asthma
Pascal Demoly, Dany Jaffuel, Jean Bousquet, Philippe Godard, and François-Bernard Michel

Reviews

"The 80 pulmonary experts and allergy specialists who collaborated on this book explore the oral, sublingual, local nasal, and local bronchial routes for noninjection immunotherapies. "-Respiratory Reviews