Table of Contents

Rationale and Historical Perspective of Intraoperative Irradiation.- Radiobiology of Large Dose per Fraction Irradiation.- Intraoperative Electron-Beam Irradiation (IOERT): Physics and Techniques.- HDR-IORT: Physics and Techniques.- Electronic Brachytherapy/Low KV IORT: Physics and Techniques.- IORT with Electron Beam, High Dose Rate Brachytherapy or Low-KV/Electronic Brachytherapy: Methodological Comparisons.- Normal Tissue Tolerance to IOERT, EBRT or Both: Animal Studies and Clinical.- Central Nervous System Tumors.- Head and Neck Cancer.- Breast Cancer.- Lung Cancer.- Gastric Cancer.- Pancreas Cancer.- Bile Duct and Gallbladder Cancer.- Primary Colorectal Cancer.- Recurrent Colorectal Cancer.- Retroperitoneal Sarcomas.- Extremity and Trunk Soft Tissue Sarcomas.- Bone Sarcomas.- Gynecologic Malignancies.- Genitourinary Cancer.- Pediatric Malignancies.- Conclusions and Future Possibilities – IORT.