Table of Contents

Contributors, ix

Preface, xv

Part 1 Management of the potential transplant recipient

1 Selection and evaluation of the recipient (including retransplantation), 3
Audrey Coilly and Didier Samuel

2 Monitoring the patient awaiting liver transplantation, 13
Andreas Geier and Beat Müllhaupt

3 Management of portal hypertension, 26
Juan Carlos Garcia-Pagan, Juan G. Abraldes and Jaime Bosch

4 Management of renal disease in the liver transplant candidate, 39
Andrés Cárdenas and Pere Ginès

5 Management of hepatopulmonary syndrome and portopulmonary hypertension, 51
Victor I. Machicao and Michael B. Fallon

6 Psychiatric and substance abuse evaluation of the potential liver transplant recipient, 62
Thomas P. Beresford

7 Organ allocation in liver transplantation: ethics, organ supply, and evidencebased practice, 75
Nicole Siparsky, David Axelrod and Richard B. Freeman

8 Viral hepatitis and transplantation, 88
Geoffrey W. McCaughan

9 Metabolic liver diseases, 97
Maureen M.J. Guichelaar and Michael R. Charlton

10 Cholestatic and autoimmune liver disease, 110
Ulrich Beuers

11 Hepatocellular carcinoma, 121
Maria Reig, Alejandro Forner and Jordi Bruix

12 Cholangiocarcinoma, 133
Howard C. Masuoka, Gregory J. Gores and Charles B. Rosen

13 Rare indications for liver transplantation, 145
Stevan A. Gonzalez

14 Liver transplantation in HIV patients, 155
Marion G. Peters and Peter G. Stock

15 Living-donor liver transplantation, 162
Robert S. Brown Jr

16 Fulminant hepatic failure, 176
Michael A. Heneghan and William Bernal

Part 2 Donor issues and management in the perioperative period

17 Extended-criteria donor, 191
Ashraf Mohammad El-Badry and Mickael Lesurtel

18 Liver transplantation using donors after cardiac death, 201
Paolo Muiesan, Laura Tariciotti and Chiara Rocha

19 Transmission of malignancies and infection through donor organs, 216
Aaron M. Winnick and Lewis Teperman

20 The transplant operation, 229
Philipp Dutkowski, Olivier de Rougemont and Pierre-Alain Clavien

21 Difficult surgical patients, 238
Philipp Dutkowski, Stefan Breitenstein and Pierre-Alain Clavien

22 Domino and split-liver transplantation, 246
Abhideep Chaudhary and Abhinav Humar

23 Surgical aspects of living-donor transplantation, 255
Kelvin K.C. Ng and Sheung Tat Fan

24 Anesthesia, 266
Beatrice Beck-Schimmer

25 Coagulation and blood transfusion management, 276
Herman G.D. Hendriks, Ton Lisman and Robert J. Porte

26 Critical care of the liver transplant recipient, 286
Markus Béchir, Erik Schadde and Philipp Dutkowski

27 Rejection and immunosuppression trends in liver transplantation, 297
James F. Trotter

28 Vascular complications after liver transplantation, 311
Goran Klintmalm and Srinath Chinnakotla

29 Biliary complications following liver transplantation, 319
Sanna op den Dries, Robert C. Verdonk and Robert J. Porte

30 Role of histopathology, 332
Achim Weber

Part 3 Chronic problems in the transplant recipient

31 Medical problems after liver transplantation, 347
Eberhard L. Renner and Marco Puglia

32 Prevention and treatment of recurrent HBV and HCV infection, 361
Ed Gane

33 Recurrence of the original disease, 372
James Neuberger

34 Infections in the liver transplant recipient, 380
Nicolas J. Mueller and Jay A. Fishman

35 Cutaneous diseases in liver transplant recipients, 389
Sylvie Euvrard and Jean Kanitakis

36 Post-transplant lymphoproliferative disorder and other malignancies after liver transplantation, 398
Natasha Chandok and Kymberly D.S. Watt

37 Sexual function and fertility after liver transplantation, 406
Andreas Geier and Beat Müllhaupt

Part 4 Pediatric liver transplantation

38 Special considerations in pediatric liver transplantation, 419
Brandy Ries Lu and Ronald J. Sokol

Multiple choice questions, 431

Answers, 446

Index, 451

About the Author

Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed),Professor and Chairman, Department of Surgery. Head, Division ofVisceral & Transplantation Surgery, University Hospital Zurich,Switzerland Professor Clavien is a world-wide renowned surgeon-scientist,currently professor and chairman of the Department of Surgery inZurich, Switzerland. His areas of research include organpreservation, liver ischemia-reperfusion injury and regeneration,and pathogenesis of cancer, as well as outcome research. Hereceived many competitive grants and awards, including one of themost prestigious prices for scientific research, the Otto NaegeliAward. Dr James Trotter is the Medical Director of LiverTransplantation at Baylor University Medical Center at Dallas. Dr.Trotter's primary interests include end-stage liver disease and themanagement of liver transplant candidates and recipients. Dr.Trotter specializes in hepatitis C, ascites, complications ofportal hypertension, including esophageal varices and hepaticencephalopathy. He also has vast experience in the management ofmedical complications after liver transplantation includingimmunosuppression in liver transplant recipients and the treatmentof hepatitis C before and after liver transplantation.

Reviews

I can recommend the book with enthusiasm. It will find aplace on my bookshelf. (Gastroenterology, 1December 2012) This new edition does a good job addressing more currentissues in liver transplantation. It succinctly provides anexcellent base of understanding, guiding readers through a varietyof indications for liver transplantation to help them understandthe operative and chronic management of thesepatients. (Doody s, 20 July 2012)