Table of Contents

Part 1 Basic concepts - lung and critical care
1: Mark Griffiths, Mary White, and Nirmala Chakkalakal: History of Mechanical Ventilation
2: Richard Leach: The Respiratory System
3: Andrew Cumpstey and Mike Grocott: Gas Exchange
4: Thomas S. Wilkinson: Airway Defences
Part 2 The Critical Care Unit
5: Judit Orosz and Steve McGoughlin: Organisation
6: Richard Keays: Emergency Planning and Disaster Management
Part 3 Non-invasive Ventilation
7: Federico Longhini, Paolo Navalesi, Mariachiara Ippolito, and Cesare Gregoretti: High Flow Nasal Oxygen Therapy
8: Cesare Gregoretti, Andrea Cortegiani, Vincenzo Russotto, and Lara Pisani: Non invasive Ventilation in Critical Care
9: Federico Longhini, Rosanna Vaschetto, and Paolo Navalesi: Clinical applications of Non invasive ventilation in Critical Care
10: Lorenzo Ball, Francesco Tasso, Veronica Vercesi, Marco Tixi, Iacopo Firpo, and Paolo Pelosi: Medical Gases and Humidification
Part 4 Basic Concepts in Positive Pressure Ventilation
11: Christoph Boesing, Thomas Luecke, and Joerg Krebs: Mechanical Ventilation: how to set up the ventilator
12: Pedro Leme Silva, Gary Nieman, Paolo Pelosi, and Patricia RM Rocco: Pulmonary effects of Positive Pressure Ventilation
13: Pedro Leme Silva, Gary Nieman, Paolo Pelosi, and Patricia RM Rocco: Extrapulmonary effects of Positive pressure Ventilation
Part 5 Monitoring the Mechanically Ventilated Patient
14: Anthony Rostron, Thomas Hellyer, and A John Simpson: Monitoring airway inflammation and infection
15: Paolo Formenti and John J Marini: Monitoring lung protective ventilation
16: Benjamin Garfield and Sunil Patel: Monitoring Respiratory muscle function
17: Rodney A Gabriel and Michael R Pinksy: Monitoring Cardiovascular function in Critically Ill patients
18: Arjun Nair: Imaging Critically Ill patients
19: Suveer Singh: Bronchoscopy in Critical Care
Part 6 Advanced Mechanical Ventilation
20: Johannes M Huitink and Lorenz G Theiler: Airway Management
21: Michele Umbrello, Paolo Formenti, and Davide Chiumello: Acute Respiratory Distress Syndrome
22: Stephan Ehrmann, Nicole P. Juffermans, Marcus J. Schultz, Nicolò Patroniti, Alex Molin, Martin Scharffenberg, Sabine Nabecker, and Marcelo Gama de Abreu: Advanced Respiratory Therapies: Inhaled therapies, Heliox, ECMO and ECCO2-R, Non conventional ventilatory modes
Part 7 Care of the ventilated patient
23: Emma Louise Hartley and Andrew Retter: Thromboprophylaxis
24: Hollmann D. Aya and Maurizio Cecconi: Fluid Balance
25: Yahya Shehabi and Maja M. Green: Sedation, Analgesia, and Paralysis
26: Danielle E Bear and Zudin Puthucheary: Nutrition
27: Mette Krag, Morten Hylander Møller, Suveer Singh, and Matt P Wise: Gastric Protection
28: Susannah Leaver and Jonathan Ball: Mucus and Bronchopulmonary clearance
29: Ahmed Al-Hindawi, Eli Rogers, and Marcela P. Vizcaychipi: Delirium and Sleep
30: Bronwen Connolly and Paul Twose: Physiotherapy
31: Christopher D Hingston: Human Factors and End of Life
Part 8 Respiratory Infections
32: Vimal Grover and Suveer Singh: Ventilator associated pneumonia
33: David R. Woods and Ricardo J. José: Bacterial Pneumonia
34: Jordi Rello, Eleonora Bunsow, and Leonel Lagunes: Viral Pneumonias
35: Jonathon P. Fanning, Gianluigi Li Bassi, Patricia Rieken Macedo Rocco, Lorenzo Ball, Antonio Messina, Marlies Ostermann, Matteo Bassetti, and Daniele Roberto Giacobbe: COVID-19 in the intensive care unit: Epidemiology, Pathophysiology, Respiratory management, Haemodynamic support, Renal support, Pharmacological treatments and Superinfection
36: Loïc Lang-Lazdunski: Pleural infection
37: Matteo Bassetti, Alessia Carnelutti, and Elda Righi: Fungal respiratory Infections
38: Christopher M. Orton, Hannah Jarvis, and Onn Min Kon: Mycobacterial Infections
39: Dhruva Chaudhry, Pawan Kumar Singh, and Manjunath B. Govindagoudar: Traveller's Pneumonia
40: Vanya Gant, and Cabeza Brason: Microbiology and Infectious Diseases Consultant Barts Health NHS Trust, London, UK
Part 9 Critical Care management of Pulmonary Diseases and other Respiratory manifestations
41: Andrea Carsetti and Simone Bazzurro: Chronic obstructive pulmonary disease
42: Mara Ricci, Giovanni Carmine Iovino, Lucrezia Mincione, Ivan Dell'atti, and Salvatore Maurizio Maggiore: Asthma
43: Caroline Patterson and Derek Bell: Thromboembolic disease
44: Vasilis Kouranos: Pulmonary Haemorrhage
45: Laura C Price, S John Wort, and Simon J Finney: Pulmonary Hypertension and Cor Pulmonale
46: Peter M George, Suveer Singh, and Felix Chua: Organising Pneumonia
47: Philip Molyneux and Athol U Wells: Interstitial Lung disease
48: Nilima Parry-Jones, Jack Parry-Jones, and Matt P Wise: The Haematological patient
49: Hemang Yadav, Alastair C Carr, and Philippe R Bauer: Oncological aspects of respiratory critical care
50: Muriel Fartoukh, Guillaume Voiriot, Aude Gibelin, Julien Lopinto, Armand Mekontso-Dessap: Sickle cell disease
51: Michael I Polkey: Neuromuscular disease
52: Fraser Brims and Edward TH Fysh: Pleural Disease
53: Thomas Kiss and Marcelo Gama de Abreu: Chest wall disease and Post thoracic surgery
54: Audrey de Jong and Samir Jaber: Obesity
55: Timothy Scott and Christopher M R Satur: Trauma
56: Giorgio della Rocca and Luigi Vetrugno: Pneumothorax and Air Leaks
57: Timothy Crozier: The Obstetric patient
58: Markus Honickel, Oliver Grottke, and Rolf Rossaint: Transfusion
59: Jasmeet Soar, Fiona Moghaddas, and Stephen M. Robinson: Anaphylaxis
60: Simone Bazurro, Andrea Carsetti, and Greg McAnulty: Aspiration and Drowning
61: Sabri Soussi, Matthieu Legrand, and Suveer Singh: Burns and Inhalation Injury
62: Omender Singh, Suneel Kumar Garg, and Deven Juneja: Poisoning
63: Thomas Bein and Michael Pfeifer: Lung Transplantation
Part 10 Weaning and Long-term ventilation
64: Patrick B Murphy, Andrew Jones, and Luigi Camporota: Liberation from Mechanical Ventilation
65: Rachel d'Oliveiro and Michael Davies: Home Mechanical Ventilation

About the Author

Dr Singh's academic career combines full time clinical work, with high educational and research output, within Respiratory and Critical Care Medicine. He works in one of the UK's national ECMO centres, leading the follow up service, and in Burns-General ICU. His Grant funded collaborative research is in early diagnostic markers for Ventilator associated pneumonia, behavioural aspects of antibiotic stewardship, safe practice of bronchoscopy in ICU, and Burns
inhalation injury. He supervises MD, PhD, MSc, BSc students. He was Imperial College Campus Director of Undergraduate Studies, and is Examiner to the Royal College of Physicians, Faculty of Intensive Care
Medicine, European Society of Intensive Care. Paolo Pelosi: Full Professor in Anaesthesiology and Critical Care, University of Genoa, Genoa, Italy.
Director of Anaesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. Director of Regional Poison Control Center, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. Fellow of the European Respiratory Society (FERS). Fellow of the Brasilian Academy of Medical Sciences. Dr Conway Morris undertook his undergraduate training at the University of Glasgow before moving to Edinburgh to train in anaesthesia
and intensive care medicine. He completed a PhD at the University of Edinburgh on the function of neutrophils in critical illness, during which time he identified factors which pre-dispose patients to
nosocomial pneumonia as well as developing several diagnostics for pneumonia. He moved to the University of Cambridge to continue post-doctoral studies. He is currently an MRC Clinician Scientist Fellow pursuing his research in critical illness immunology and pneumonia, alongside working as a consultant in intensive care medicine in Addenbrooke's Hospital.