1. Nomenclature; 2. Overview of tissue optical properties; 3. Introduction to biomedical statistics for diagnostic applications; 4. General concepts of tissue spectroscopy and instrumentation; 5. Autofluorescence spectroscopy and reporter fluorescence; 6. Raman and infrared spectroscopy of vibrational modes; 7. Elastic and quasi-elastic scattering from cells and small structures; 8. Diffuse reflectance spectroscopy at small source-detector separations; 9. Transport theory and the diffusion equation; 10. Continuous-wave methods for tissue spectroscopy; 11. Time-domain methods for tissue spectroscopy in the diffusion regime; 12. Frequency-domain methods for tissue spectroscopy in the diffusion regime; 13. Instrumentation and experimental methods for diffuse tissue spectroscopy; 14. Diffuse optical imaging and tomography; 15. In vivo applications of diffuse optical spectroscopy and imaging; 16. Combining light and ultrasound: acousto-optics and opto-acoustics; 17. Modern optical microscopy for biomedical applications; 18. Optical coherence tomography; 19. Optical tweezers and laser-tissue interactions.
Based on physical science principles, Quantitative Biomedical Optics covers theory, instrumentation, methods and applications, with practical exercises and problem sets.
Irving Bigio is Professor of Biomedical Engineering and Electrical Engineering at Boston University. His research activities address the interactions of light with cellular and tissue structures on the microscopic and mesoscopic scales. He pioneered methods of elastic scattering spectroscopy and has developed practical diagnostic and sensing applications that have been demonstrated in large clinical studies. He has co-authored over 200 scientific publications and is an inventor on nine patents. Sergio Fantini is Professor of Biomedical Engineering at Tufts University. His research interests in biomedical optics are in the area of diffuse spectroscopy and imaging of biological tissue. He has contributed to the development of quantitative frequency-domain methods for absolute tissue oximetry, spectral imaging approaches to optical mammography, and the assessment of cerebral hemodynamics in the human brain. He has co-authored about 200 scientific publications and is an inventor on ten patents.
'Bigio and Fantini provide a long-needed introduction to the field
of biomedical optics and biophotonics, adding spice to the
presentation of the basics with historical and etymological gems.
The conversational tone of the book is very welcome, and allows
room for the clear explanation of subtleties not always clarified
in other discussions. The book is a wonderful introduction to the
field. It balances rigor with readability. Bravo!' Steven L.
Jacques, Oregon Health Sciences University
'This book about biomedical optics provides a remarkably
comprehensive introduction to the field. The text is carefully and
affectionately developed with quantitative rigor, and it is written
in a clear, easy-to-understand style that helps students develop
intuition. The subject matter covers basics of linear and nonlinear
optical spectroscopy, static and dynamic light scattering and more
advanced topics such as light transport through highly scattering
tissues, acousto-optics and opto-acoustics, and imaging from
microscopy to tomography. The book should prove useful as a
textbook for courses targeting both advanced undergraduates and
graduate students in science, engineering and medicine. It will
also be a valuable reference for researchers working at the
frontiers of knowledge.' Arjun G. Yodh, University of
Pennsylvania
'Bigio and Fantini's comprehensive text on biomedical optics
provides a wonderful blend of accessible theory and practical
guidance relevant to the design and application of biomedical
optical systems. It should be required reading for all graduate
students working in this area.' Rebecca Richards-Kortum, Rice
University, Houston
'This textbook provides a broad survey of the field and covers the
basics in a remarkably clear and easy to understand style. The
authors have used the fundamental principles of physical science to
describe subject matter and a quantitative approach for their
applications. … I highly recommend this textbook for upper-level
undergraduate courses as well as more advanced graduate-level
courses on biomedical optics. The book would also be useful for
students of the biological sciences and as a reference resource for
researchers in biomedical optics.' Reva Garg, Optics and Photonics
News
'Educators in Biomedical Optics and Biophotonics have been long
awaiting a comprehensive text to accompany their teaching in this
rapidly growing field and this is as good as it gets. Educators may
have their own bias, but this text provides a balanced approach
giving due weight to the topics within the field and covering them
comprehensively for most undergraduate and graduate courses in the
field … There is sufficient depth, detail and reference material
for very specialized researchers to use this as their 'bible' and
it should be on the desk of every serious educator and researcher
in biomedical optics.' Martin Leahy, National University of
Ireland, Galway
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