Table of Contents

Vitamin A and its natural derivatives
Chris P.F. Redfern

Post-natal all-trans-retinoic acid biosynthesis
Joseph L. Napoli

Retinoid metabolism and functions mediated by retinoid binding-proteins
Joseph L. Napoli and Hong Sik Yoo

Generation and isolation of recombinant retinoid oxidoreductase complex
Mark K. Adams, Olga V. Belyaeva and Natalia Y. Kedishvili

Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein
Brianna K. Costabile, Youn-Kyung Kim, Yunting Chen, Oliver B. Clarke, Loredana Quadro and Filippo Mancia

Use of fixatives for immunohistochemistry and their application for detection of retinoic acid synthesizing enzymes in the central nervous system
Azita Kouchmeshky and Peter McCaffery

Classical pathways of gene regulation by retinoids
Ehmke Pohl and Charles W.E. Tomlinson

Protein-protein interactions in the regulation of RAR–RXR heterodimers transcriptional activity
Albane le Maire, Pierre Germain and William Bourguet

Natural ligands of RXR receptors
Patricia García, Paula Lorenzo and Angel R. de Lera

DNA recognition by retinoic acid nuclear receptors
Carole Peluso-Iltis, Judit Osz and Natacha Rochel

Noncanonical retinoic acid signaling
Jennifer Nhieu, Yu-Lung Lin and Li-Na Wei

Retinoic acid and microRNA
Lijun Wang, Atharva Piyush Rohatgi and Yu-Jui Yvonne Wan

Analysis of vitamin A and retinoids in biological matrices
Lindsay C. Czuba, Guo Zhong, King Yabut and Nina Isoherranen

Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny
Mary Ann Asson-Batres and Christopher W. Norwood

Identifying vitamin A signaling by visualizing gene and protein activity, and by biochemical isolation of vitamin A metabolites
Stephen R. Shannon, Jianshi Yu, Amy E. Defnet, Danika Bongfeldt, Alexander R. Moise, Maureen A. Kane and Paul A. Trainor

Whole mount in situ hybridization and immunohistochemistry for studying retinoic acid signaling in developing amphioxus
Matteo Bozzo, Simona Candiani and Michael Schubert

Design of synthetic retinoids
David R. Chisholm and Andrew Whiting

Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids
Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili and Olga V. Belyaeva

Tissue localization of retinoic acid receptor (RAR) active drugs
Azita Kouchmeshky, Timothy Goodman, Andy Whiting and Peter McCaffery

The development of methodologies for high-throughput retinoic acid binding assays in drug discovery and beyond
Charles W.E. Tomlinson and Andrew Whiting

Using the human CYP26A1 gene promoter as a suitable tool for the determination of RAR-mediated retinoid activity


Reza Zolfaghari, Floyd J. Mattie, Cheng-Hsin Wei, David R. Chisholm, Andrew Whiting and A. Catharine Ross

About the Author

Ehmke Pohl is at Durham University, Durham, UK