Table of Contents

The Scope of Selectivity and Detectability Optimizations inHPLC.

Physicochemical Basis of Retention.

Probing Separation Mechanism in HPLC.

Conventional Approaches to Mobile-Phase Selection andOptimization.

Improving Separations in Adsorption for Normal-PhaseSeparations.

Selectivity Optimization in Reversed-Phase Separations.

Ion-Exchange Chromatography of Ionic and Ionizable Compounds.

Optimizing Selectivity of Ion-Pair Separations.

Macromolecular Separations.

Isomeric Separations.

Computer Optimization of Selectivity.

Selective Detectors in HPLC.

Detectability Optimization.

Index.

About the Author

About the author SATINDER AHUJA is Senior Staff Scientist in the Physical and Analytical Chemistry Division at CIBAGEIGY Corporation. He earned his PhD in pharmaceutical analytical chemistry at the Philadelphia College of Pharmacy and Science. Dr. Ahuja, who enjoys an international reputation in his field, is a member of the American Chemical Society and the editor of four books, including Ultra Trace Analysis of Pharmaceutical and Other Compounds of Interest (Wiley, 1986). His publications and presentations include basic investigations on various modes of chromatography, automation/computerization, and analytical evaluations of drug candidates.