Table of Contents

Sensitization via Membrane-Bound Receptors.- Sensitization of Epithelial Cancer Cells with Human Monoclonal Antibodies.- Targeting the Transferrin Receptor to Overcome Resistance to Anti-Cancer Agents.- Chemo-Immunosensitization of Resistant B-NHL as a Result of Rituximab (anti-CD20 mAb)-Mediated Inhibition of Cell Survival Signaling Pathways.- Agents that Regulate DR5 and Sensitivity to TRAIL.- Proteasome Inhibition: Potential for Sensitization of Immune Effector Mechanisms in Cancer.- Sensitization via Inhibition of Cell Survival Pathways (Excluding Apoptotic Signaling Pathways).- Angiogenesis Inhibitors as Enabling Agents for the Chemotherapeutic Treatment of Metastatic Disease.- Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy.- Histone Deacetylase Inhibitors and Anticancer Activity.- Eicosanoids and Resistance of Cancer Cells to Chemotherapeutic Agents.- Sensitization via Transcription Factors.- The RKIP and STAT3 Axis in Cancer Chemotherapy: Opposites Attract.- Targeting Transcription Factors with Decoy Oligonucleotides: Modulation of the Expression of Genes Involved in Chemotherapy Resistance of Tumor Cells.- p53 Inhibitors as Cancer Sensitizing Agents.- Nitric Oxide—Induced Immunosensitization to Apoptosis by Fas-L and TRAIL.- Natural Agents That Can Sensitize Tumor Cells to Chemotherapy and Radiation Therapy.- Sensitization via Targeting Apoptotic Pathways.- Inhibitors of the Bcl-2 Protein Family as Sensitizers to Anticancer Agents.- Therapeutic Targeting of Apoptosis in Cancer.- Peptides and Peptidomimetics as Cancer Therapy Sensitizing Agents.- Non-Peptidic Mimetics as Cancer-Sensitizing Agents.- Sensitization of Cancer Cells to Cancer Therapies by Isoflavone and Its SyntheticDerivatives.- Antisense Oligonucleotides and siRNA as Specific Inhibitors of Gene Expression: Mechanisms of Action and Therapeutic Potential.- Sensitization Tailored to Individual Patients.- DNA Polymorphisms Affecting Chemosensitivity Toward Drugs.- Pharmacogenetics in Cancer Management: Scenario for Tailored Therapy.

Reviews

From the reviews: “This book introduces emerging strategies, potential signaling pathways and biomolecules as key targets to sensitize resistant cancers. … detailed information and data can be obtained from the references listed at the end of each chapter. This book helps chemists to enrich their biological insight, and biologists to acquire new chemical strategies in reversing cancer resistance. … the book is also recommended to students in these fields. For scientists in industry and academia, and clinicians, this book provides an overview of current approaches … .” (Yoshihiko Kotake, ChemMedChem, Vol. 4, 2009)